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Uncontrolled hypertension despite treatment with two or more antihypertensive medications "Uncontrolled" generally means a systolic blood pressure consistently above 140 or a diastolic above 90 despite ongoing treatment with at least two antihypertensive medications from different drug classes (such as an ACE inhibitor or ARB, a calcium channel blocker, a thiazide diuretic, or a beta-blocker)

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This pricing structure makes continuous therapy economically viable for patients without insurance coverage